Fri Oct 21 2022

47 articles - From Friday Oct 14 2022 to Friday Oct 21 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Rheumatology (Oxford)

Assessment and diagnosis of the acute hot joint: A systematic review and meta-analysis.

Our review demonstrates many single tests, individually with diagnostic utility but suboptimal accuracy for exclusion of native joint infection. A combination of several tests +/- stratification score is required to optimise rapid assessment of the hot joint.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study.

Epidemiological data on SLE are lacking for 79.8% of countries worldwide. The epidemiology of SLE varies substantially between different sex and age groups and is distributed unequally among geographical regions; specifically, SLE occurs more frequently in high-income countries.

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Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis.

Together, these findings suggest that myeloablative autologous HSCT resets the IGH repertoire to a more naïve state characterised by IgM-expressing B cells, providing a possible mechanism for the elimination of pathogenic B cells that may contribute to the benefit of HSCT over CYC in the treatment of dcSSc.

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Stage-specific and location-specific cartilage calcification in osteoarthritis development.

This work refines our current understanding of the mechanism underlying OA progression and provides the foothold for potential therapeutic targeting strategies once the location-specific cartilage calcification features in OA are established.

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Tenderness and radiographic progression in rheumatoid arthritis and psoriatic arthritis.

Our findings imply that tenderness in non-swollen joints in RA is associated with subsequent damage. In both diseases, additional risk factors, such as sonographic signs for synovitis and baseline radiographic damage are associated with radiographic progression.

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Arthritis Care Res (Hoboken)

Association Between Race/Ethnicity and COVID-19 Outcomes in Systemic Lupus Erythematosus (SLE) Patients from the United States: Data from the COVID-19 Global Rheumatology Alliance.

Black and Hispanic individuals with SLE experienced more severe COVID-19 outcomes, which is consistent with findings in the US general population. These results likely reflect socioeconomic and health disparities and suggest that more aggressive efforts are needed to prevent and treat infection in this population.

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Identification of Symptoms Phenotypes of Hand Osteoarthritis using Hierarchical Clustering: Results from the DIGICOD Cohort.

The identification of distinct clinical clusters based on HOA cardinal symptoms suggests previously undescribed subtypes of this condition warranting further study of biological characteristics of such clusters and opening a path toward phenotype-based personalized medicine in HOA.

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Identifying Inflammation in Knee Osteoarthritis: The Relationship of Synovial Fluid White Blood Cell Count to MRI Effusion-Synovitis.

The sensitivity and specificity of SF WBC in identifying E-S on MRI were limited. Further research is needed to better understand the association between MRI and SF measured E-S and to determine which measure more strongly relates to synovial histopathology and patient outcomes.

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Predictors of Patient and Physician Assessments of Gout Control.

For both patients and physicians, absence of gout flares and serum urate levels at the treatment target predict assessment of gout control. However, discordance between patients and physicians in their assessment of disease control is not uncommon, with recent gout flares and tophus predicting lower scores by physicians than patients.

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The Cost-Effectiveness of Weight Loss Interventions Prior to Total Knee Replacement for Patients with Class III Obesity.

For patients with Class III obesity considering TKR, RYGB provides good value while immediate TKR without weight loss is not economically efficient.

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Arthritis Res Ther

Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis.

CAT-1 is upregulated and promotes FLS proliferation by taking up L-arginine, thereby promoting RA progression.

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Comorbidity phenotypes and risk of mortality in patients with osteoarthritis in the UK: a latent class analysis.

This study identified six comorbidity clusters in individuals with OA and matched controls within this cohort. Opioid use and comorbidity clusters were differentially associated with the risk of mortality. The analyses may help shape the development of future interventions or health services that take into account the impact of these comorbidity clusters.

Pubmed   Journal   ReadQx   PMC

Differences in trajectory of disease activity according to biologic and targeted synthetic disease-modifying anti-rheumatic drug treatment in patients with rheumatoid arthritis.

The trajectory-based approach was useful for clustering the treatment response of biologic and targeted synthetic DMARDs in patients with RA. In addition, baseline DAS28, ESR, prednisolone dose, eGFR, and BUN were important contributing factors for 4-year trajectories.

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Impact of cardiovascular risk on the diagnostic accuracy of the ultrasound Halo Score for giant cell arteritis.

Elevated CVR may influence the diagnostic accuracy of the US Halo Score for GCA. Thus, CVR should be taken into consideration in the US screening for GCA.

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Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model.

SAMP8 are a spontaneous OA model that is useful for investigating the pathogenesis of primary OA and evaluating therapeutic interventions.

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Arthritis Rheumatol

A Flare Risk Index Informed by Select Immune Mediators in Systemic Lupus Erythematosus.

We verified altered immune mediators associated with imminent disease flare; a subset improved the FRI to identify SLE patients at risk of imminent flare. This molecularly-informed proactive management approach could be critical in prospective clinical trials and the clinical management of lupus.

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Association of antibodies to Prevotella copri in anti-CCP-positive individuals at-risk for developing rheumatoid arthritis and in those with early or established rheumatoid arthritis.

These findings support a potential etiologic role for this microorganism in both RA preclinical evolution and the subsequent pathogenesis of synovitis.

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CXCL5 administration dampens inflammation and improves survival in murine lupus via myeloid and neutrophil pathways.

Taken together, CXCL5 administration may represent a novel myeloid/neutrophil-targeting therapy for SLE.

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Incidence, Prevalence, and Mortality of Lupus Nephritis: A Population-Based Study Over Four Decades-The Lupus Midwest Network (LUMEN).

The incidence and prevalence of LN in this area increased in the last four decades. LN patients have poor outcomes with high rates of ESRD and mortality rates six times that of the general population.

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Integrative functional genomics identifies SLE causal genetic variant in the IRF5 risk locus.

These results demonstrate that rs4728142-A allele increases the SLE risk by affecting ZBTB3 binding, chromatin status, and regulating IRF5 expression, establishing a biological link between genetic variation and lupus pathogenesis.

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Platelet LGALS3BP Induces Myeloid Inflammation In Systemic Lupus Erythematosus.

These data support that platelets act as potent effector cells contributing to the pathogenesis of SLE by secreting proinflammatory LGALS3BP, which also represents a novel biomarker of SLE clinical activity.

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Reset of inflammatory priming of joint tissue and reduction of the severity of arthritis flares by bromodomain inhibition.

Inflammatory tissue priming is dependent on transcriptional regulation by BET proteins, which makes them promising therapeutic targets for preventing arthritis flares in previously affected joints.

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The CRTAC1 protein in plasma associates with prevalent osteoarthritis and predicts future risk as well as progression to joint replacements - Results from the UK Biobank resource.

CRTAC1 in plasma is specific biomarker of OA, and predictor of OA risk and progression to joint replacements. Adding ACAN and NCAN to CRTAC1 improves the prediction of OA.

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Rheumatology (Oxford)

Analyses of plasma inflammatory proteins reveal biomarkers predictive of subsequent development of giant cell arteritis: a prospective study.

Elevated IFN- levels were found years prior to diagnosis of GCA. T cell activation may precede the clinical onset of GCA.

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Angiotensin receptor blockade is associated with increased risk of giant cell arteritis.

Initiation of ARB is associated with higher risk of GCA compared with ACEi or other antihypertensives. Mechanistic studies of angiotensin receptor biology will provide further clarity for our findings.

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Anti-transcription intermediary factor 1-gamma IgG2 isotype is associated with cancer in adult dermatomyositis: an ENMC multinational study.

These results suggest considering anti-TIF1 IgG2 ALBIA and IgG ELISA values as biomarkers of cancer in anti-TIF1 aAb-positive adult DM.

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Antiphospholipid antibody positivity in early systemic lupus erythematosus is associated with subsequent vascular events.

Double/triple-positivity for IgG anti-CL, anti- anti-ß2GPI and anti-DI in early SLE identifies a population at higher risk of subsequent VE.

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Autoimmune activation and hypersensitization of the AT1 and ETA receptors contributes to vascular injury in scleroderma renal crisis.

We provide experimental evidence that agonistic Abs may contribute to SRC. This effect is presumably related to direct receptor stimulation and additional allosteric effects, at least in heterodimeric receptor constellations. Novel therapies targeted at autoimmune hyperactivation of AT1R and ETAR might improve outcomes in severe cases of SRC.

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Citrullinated and carbamylated proteins in extracellular microvesicles from plasma of patients with Rheumatoid Arthritis.

The results of this study suggest an involvement of EMVs in the pathogenesis of RA by inducing autoimmunity.

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Genetic architecture underlying IgG-RF production is distinct from that of IgM-RF.

We found a unique genetic architecture of IgG-RF(-) RA, which showed a strong association with the SE allele less frequent among Japanese but the most frequent in Europeans. The findings could shed light on uncovered RA pathology.

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Grit personality of physicians and achievement of treatment goals in patients with systemic lupus erythematosus.

Difficulty of attending physicians to change treatment goals might be related to lower LLDAS achievement in patients with SLE.

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Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination.

Following two doses, most RAIRD patients have lower antibody levels than the lowest HC and lower anti-spike T cells. RAIRD patients with low/no antibodies have diminished numbers and poor quality of memory T cells which lack proliferative and functional capacities.

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The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritis.

Anti-CCP2, load of ACPA fine-specificities, and IgM RF at RA diagnosis are associated with an increased risk of future VTE in RA. Antibodies to citrullinated fibrinogen did not differ substantially from other ACPA fine-specificities. Autoreactivity to other post-translational modifications were not associated with VTE risk.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Rheum Dis

COP27 climate change conference: urgent action needed for Africa and the world.

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Efficacy and safety of non-pharmacological and non-biological interventions: a systematic literature review informing the 2022 update of the ASAS/EULAR recommendations for the management of axial spondyloarthritis.

Education, exercise and NSAIDs confirmed to be efficacious in axSpA. JAKi were proved efficacious in r-axSpA.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Rheum Dis

Database of synovial T cell repertoire of rheumatoid arthritis patients identifies cross-reactive potential against pathogens including unencountered SARS-CoV-2.

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News from EULAR.

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Pyrogenic lower limbs.

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Arthritis Rheumatol

Impending cardiac tamponade and coated aorta: Erdheim-Chester disease.

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Rheumatology (Oxford)

COP27 Climate Change Conference: urgent action needed for Africa and the world.

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Is the parent global assessment a reliable quality of life measure in juvenile idiopathic arthritis?

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SNP-based heritability estimates of gout and its subtypes determined by genome-wide association studies of clinically defined gout.

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Letters&Replies

Letters to the editors and authors’ replies

Arthritis Care Res (Hoboken)

Comment on: Predictors of osteonecrosis in systemic lupus erythematosus. A prospective study.

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Obesity, sarcopenia and arthritis: the theory of relativity.

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Reply to: Obesity, sarcopenia and arthritis: the theory of relativity.

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Arthritis Res Ther

Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis.

ACPA-expressing B cells are not enriched for EBV-DNA-containing clones. These results do not support the hypothesis that EBV infection of autoreactive B cells causes or maintains autoreactive B cell populations in RA. Instead, other mechanisms might explain the association between positive EBV serology and RA.

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Arthritis Rheumatol

SERONEGATIVE PALINDROMIC RHEUMATISM. WHAT ARE WE TALKING ABOUT? Response to Yang et al. Arthritis Rheumatology 2022 Jul 12. doi:10.1002/art.42297.

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